Monday, November 20, 2017

The difference between Prodrugs and Soft Drugs

• However, it is possible to design a pro-soft drug, a modified soft drug that requires metabolic activation for convers...
• Classification of soft drugs:• Soft drugs are divided by Bodor into five different groups1.Soft analogs2.Activated soft...
• Soft analogs:• Soft analogs are close structural analogs of known active drugs or bio active compounds• These compounds...
• The simplest example of the soft analog is the isosteric analog (II) of cetylpyridinium chloride (I) which is a hard q...
• Activated soft compounds:• These compounds are not the analogs of known drugs• These are designed by introducing a pha...
Eg: soft chloramine are less corrosive(where thechlorine atom attached to hetero atom) than theconventional chloraminesEg:...
• Natural soft drugs:• The endogenous substances can be considerd as natural soft drugs since the body possesses efficie...
Eg: the use of di esters of adrenalone todeliver the epinephrine the eye via combinedreduction and hydrolysis process .
• Soft Drugs based on active metabolite approach:• Some drugs under go step wise biotransformation giving intermediates ...
• Eg: Oxyphenbutazone the active p-hydroxy metabolite of phenylbutazone• Oxazepam the common active metabolite of chlord...
• Soft Drugs based on inactive metabolite approach:• This is done by three stepsa)Activation stage: chemical modification...
c)Controllable metabolism: control of transportand binding properties as well as rate ofmetabolism and pharmacokinetics by...
References:Andrejus Korolkovas ESSENTIALS OF MEDICINAL CHEMISTRY, 2ND EDFriary, R. Jobs in the Drug Industry A Career Guid...
Soft and hard drugs
Soft and hard drugs
Soft and hard drugs
Soft and hard drugs
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