• Drugs – natural and synthetic alike – are chemicals used for medicinal purposes.
They interact with complex chemical systems of humans or animals.
• Medicinal chemistry is concerned with this complex interaction, focusing on the
organic and biochemical reactions of drug substances with their targets.
• Other important aspects are the synthesis and the analysis of drug substances. The
two latter aspects together are sometimes called Medicinal Chemistry, but the
synthesis of drugs is considered by some people – mainly chemists – to be part of
medicinal chemistry, denoting analytical aspects as pharmaceutical chemistry.
Objectives
The objective of Medicinal chemistry is to: Find, develop and improve drug substances that
cure or alleviate diseases and understand the causative and accompanying chemical
processes .
Medicinal chemistry is an interdisciplinary science covering a particularly wide domain
situated at the interface of organic chemistry with life sciences, such as biochemistry,
pharmacology, molecular biology, genetics, immunology, pharmacokinetics and toxicology
on one side, and chemistry-based disciplines such as physical chemistry, crystallography,
spectroscopy and computer-based techniques of simulation, data analysis and data
vis4ualization on the other side
Definition of medicinal chemistry (given by a IUPAC specialized commission)
Medicinal chemistry concerns the discovery, the development, the identification and
the interpretation of the mode of action of biologically active compounds at the
molecular level.
• Emphasis is put on drugs, but the interests of the medicinal chemist are not
restricted to drugs but include bioactive compounds in general.
• Medicinal chemistry is also concerned with the study, identification, and
synthesis of the metabolic products of various drugs and related compounds.
Medicinal chemistry is a chemistry-based discipline, involving aspects of
biological, medical and pharmaceutical sciences. It is concerned with the
invention, discovery, design, identification and preparation of biologically
active compounds, the study of their metabolism, the interpretation of their
mode of action at the molecular level and the construction of structure-
activity relationships (SARs).
Structure-activity relationship (SAR) is the relationship between chemical
structure and pharmacological activity for a series of compounds.
Lead compound is a compound that has a desirable biological activity with
therapeutic relevance, but typically has some shortcoming that is likely to be
overcome through the development of analogs.
They interact with complex chemical systems of humans or animals.
• Medicinal chemistry is concerned with this complex interaction, focusing on the
organic and biochemical reactions of drug substances with their targets.
• Other important aspects are the synthesis and the analysis of drug substances. The
two latter aspects together are sometimes called Medicinal Chemistry, but the
synthesis of drugs is considered by some people – mainly chemists – to be part of
medicinal chemistry, denoting analytical aspects as pharmaceutical chemistry.
Objectives
The objective of Medicinal chemistry is to: Find, develop and improve drug substances that
cure or alleviate diseases and understand the causative and accompanying chemical
processes .
Medicinal chemistry is an interdisciplinary science covering a particularly wide domain
situated at the interface of organic chemistry with life sciences, such as biochemistry,
pharmacology, molecular biology, genetics, immunology, pharmacokinetics and toxicology
on one side, and chemistry-based disciplines such as physical chemistry, crystallography,
spectroscopy and computer-based techniques of simulation, data analysis and data
vis4ualization on the other side
Definition of medicinal chemistry (given by a IUPAC specialized commission)
Medicinal chemistry concerns the discovery, the development, the identification and
the interpretation of the mode of action of biologically active compounds at the
molecular level.
• Emphasis is put on drugs, but the interests of the medicinal chemist are not
restricted to drugs but include bioactive compounds in general.
• Medicinal chemistry is also concerned with the study, identification, and
synthesis of the metabolic products of various drugs and related compounds.
Medicinal chemistry is a chemistry-based discipline, involving aspects of
biological, medical and pharmaceutical sciences. It is concerned with the
invention, discovery, design, identification and preparation of biologically
active compounds, the study of their metabolism, the interpretation of their
mode of action at the molecular level and the construction of structure-
activity relationships (SARs).
Structure-activity relationship (SAR) is the relationship between chemical
structure and pharmacological activity for a series of compounds.
Lead compound is a compound that has a desirable biological activity with
therapeutic relevance, but typically has some shortcoming that is likely to be
overcome through the development of analogs.
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