Prodrugs
Prodrugs are pharmacologically inactive derivatives of active drugs. They are designed to maximize the amount of active drug that reaches its site of action, through manipulation of the physicochemical, biopharmaceutical or pharmacokinetic properties of the drug. Prodrugs are converted into the active drug within the body through enzymatic or non-enzymatic reactions.
Soft drugs
Drugs are sometimes divided into "hard drugs " and "soft drugs". Hard drugs are "non-metabolizable drugs" or drugs which are metabolized to biologically active metabolites. The metabolites of hard drugs are frequently toxic oxidation products. Soft drugs are drugs which are characterized by a predictable and controllable in vivo destruction (i.e. metabolism) to non-toxic products after they have achieved their therapeutic role.
Similarly "hard compounds" can be defined as compounds which do not degrade in the environment or compounds which do it very slowly. Thus, these compounds will lead to progressive pollution of the environment. An example of a hard compound is the insecticide DDT.
"Soft compounds" can be defined as biologically active compounds which are readily degraded to non-toxic and biologically inactive degradation products in the environment. The purpose of this project is to design, synthesise and test soft drugs and soft environmental-friendly compounds
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